2019-novel Coronavirus Disease (COVID-19) pandemic has recently struck Northern Italy.

Limited data are available about COVID-19 during pregnancy and infancy, mostly from China.

 Herein, our experience on a safe perinatal management of neonates born to COVID-19 mothers is reported.

 Since late February through May 15, 2020, 375 pregnant women delivered at our City Hospital in Piacenza, at the epicenter of the Italian epidemic.

 Of these, 144 were tested via a SARS-CoV-2 quantitative rRT-PCR nasopharyngeal swab prior to delivery, firstly on the basis of epidemiological and clinical criteria, then adopting a universal screening approach.

 All newborns from SARS-CoV-2 positive mothers were tested via nasopharyngeal swab at birth, on day 3 and/or day 7.