Maternally derived antibodies are a key element of neonatal immunity.

Understanding the dynamics of maternal antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy and subsequent transplacental antibody transfer can inform neonatal management as well as maternal vaccination strategies.

We assess the association between maternal and neonatal SARS-CoV-2–specific antibody concentrations.

This cohort study took place at Pennsylvania Hospital in Philadelphia, Pennsylvania. A total of 1714 women delivered at the study site between April 9 and August 8, 2020.

Maternal and cord blood sera were available for antibody measurement for 1471 mother/newborn dyads.