While some studies have found an association between marijuana use and adverse neonatal outcomes, results have not been consistent across all trials.
We assess available data on neonatal outcomes in marijuana-exposed pregnancies.
PubMed, Medline, ClinicalTrials.gov, Cochrane, Scopus, and Web of Science were searched from each database's inception until August 16, 2021.
All interventional and observational studies that included pregnant women who were exposed to marijuana compared with pregnant women who were not exposed to marijuana and that reported neonatal outcomes were included.
Data Extraction and Synthesis Reporting followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses guideline.
Data were extracted by 2 authors for all outcomes, which were pooled using a random-effects model as mean difference or risk ratio (RR) and 95% CI.
Data were analyzed from August through September 2021.