Pain management is important for newborns’ immediate and long-term well-being.

While intranasal analgesia and sedation have been well studied in children, their use could be extended to term and preterm infants.

This systematic review aims to assess the use of intranasal medications for procedural analgesia or sedation in the neonatal intensive care unit.

MEDLINE via Ovid, Scopus, Embase, and Cochrane Library were searched independently by two reviewers for clinical studies on sedation or analgesia given intranasally.